I would chip in first the Brera should really only be considered a two seater with space in the back as useful as a chocolate fireguard, you will never see a Brera with poor condition back seats simply because they are never used so if you have 2 10 year olds forget it you will simply ruin the seats getting in and out.
What you need to look out for as previously said regular oil changes half what the service book says.
One weak point which as you approach higher miles be prepared for a gearbox refurb, 2.2 fitted with M32 gearbox, top gear bearings wear common problem from over heating and lack of oil, when it goes, if you budget £1500 you can get an exchange unit and 12 months warranty from Autolusso, mine has started to make a slight noise at just over the 90k mark so is next on my list to fix after fitting a new set of rubber.
V6 has a different box I believe, clearly the box they fitted in the 2.2 came from the GM parts bin and was not fit for purpose and is known to have had issues in other cars Saab, Vauxhall.
Check also if the drivers wiper catches the bonnet another problem that is a easy fix plenty of threads on here, but worth checking and if you can get the garage to sort it before you buy one job less.
No doubt there will be many arguments on here which is best 2.2 v V6 as there are with petrol and diesel and some become rather petty or not relevant in my view take the car for what it is a tourer whether you have the V6 or 2.2 it is not a sports car it is too heavy, yes the V6 has more power but is heavier, if you want sport performance dont buy a Brera buy a Boxster, and if you have 2 10 year olds to consider in the back I would go for a M3 instead.
Last edited by Camerondawn; 19-02-15 at 15:07.